Activation of AMPK sensitizes medulloblastoma to Vismodegib and overcomes Vismodegib‐resistance
نویسندگان
چکیده
منابع مشابه
Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib.
Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is rare in adults. Medulloblastomas fall into 4 prognostically significant molecular subgroups that are best defined by experimental gene expression profiles: the WNT pathway, sonic hedgehog (SHH) pathway, and subgroups 3 and 4 (non-SHH/WNT). Medulloblastoma of adults belong primarily to the SHH category. Vi...
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ژورنال
عنوان ژورنال: FASEB BioAdvances
سال: 2021
ISSN: 2573-9832,2573-9832
DOI: 10.1096/fba.2020-00032